| Protection of 3’-methoxy-puerarin against focal brain ischemia and its association with c-fos expression |
| |
| 摘 要： | The present study established a rat model of focal brain ischemia by occlusion of the middle cerebral artery covered with FeCl3, and investigated the protective effect of 3’-methoxy-puerarin. Hippocampal and cortical c-fos gene expression was determined using in situ hybridization. Results showed that 3’-methoxy-puerarin reduced neurological deficit scores, cerebral infarcted zone and water content of brain tissues, dramatically increased the activity of catalase and glutathione peroxidase in the ischemia zone of the hippocampus, increased the activity of catalase in the cortex, decreased lipid peroxide and lactic acid contents in the hippocampus and cerebral cortex, and down-regulated c-fos gene expression in brain ischemic rats. Results demonstrated that 3’-methoxy-puerarin exhibited cerebroprotective effects against focal brain ischemia, which involved c-fos gene expression.
|
| 关 键 词： | focal brain ischemia 3’-methoxy-puerarin puerarin c-fos gene protect neural regeneration |
Protection of 3'-methoxy-puerarin against focal brain ischemia and its association with c-fos expression |
| |
| Sha Liu,Yibing Zhang,Guiyou Du,Yong Zhao,Haifeng Cui,Chunyu Cao School of Traditional Chinese Medicine,Chongqing Medical University,Chongqing ,China Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing ,China. Protection of 3'-methoxy-puerarin against focal brain ischemia and its association with c-fos expression[J]. Neural Regeneration Research, 2011, 6(27): 2094-2099 |
| |
| Authors: | Sha Liu Yibing Zhang Guiyou Du Yong Zhao Haifeng Cui Chunyu Cao School of Traditional Chinese Medicine Chongqing Medical University Chongqing China Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China |
| |
| Affiliation: | Sha Liu1,Yibing Zhang1,Guiyou Du2,Yong Zhao2,Haifeng Cui2,Chunyu Cao2 1School of Traditional Chinese Medicine,Chongqing Medical University,Chongqing 401331,China 2Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China |
| |
| Abstract: | |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
|
