| Isatin decreases Bax protein expression in the substantia nigra of a mouse model of Parkinson’s disease |
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| 基金项目： | a grant from Shandong Provincial Education Department, No. J08LH54 |
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| 摘 要： | The present study observed the action of 1H-indole-2, 3-dione (isatin) on Bax protein expression in the substantia nigra of a Parkinson’s disease animal model. Parkinson’s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Bax protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein express...
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Isatin decreases Bax protein expression in the substantia nigra of a mouse model of Parkinson's disease |
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| Authors: | Jiguo Zhang Fang Zhang Yanlong Qiu Wang Yue |
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| Institution: | Jiguo Zhang1,Fang Zhang2,Yanlong Qiu1,Wang Yue2 1Department of Pharmacology,Taishan Medical University,Taian 271016,Shandong Province,China 2Department of Pharmacology,Qingdao University Medical School,Qingdao 266021,China |
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| Abstract: | The present study observed the action of 1H-indole-2, 3-dione (isatin) on Bax protein expression in the substantia nigra of a Parkinson's disease animal model. Parkinson's disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Bax protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein expression. |
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| Keywords: | 1H-indole-2 3-dione (isatin) Parkinson's disease 1-methyl-4-phenyl-1 2 3 6- tetrahydropyridine Bax mouse neurodegenerative disease neural regeneration |
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