氨氯地平联合替米沙坦治疗对老年轻、中度高血压病患者左心室结构和功能的影响

目的：探讨氨氯地平联合替米沙坦治疗对老年轻中度高血压病患者左心室结构和功能的影响。方法：选择50例老年原发性轻中度高血压病伴左心室肥厚患者,给予氨氯地平（2.5 mg）联合替米沙坦（40 mg）治疗24个月,治疗前及治疗后24月分别进行血压测量及超声心动图检查,对参数（左室舒张末期内径、左室后壁舒张末期厚度、室间隔舒张末期厚度、左室心肌重量指数、左室射血分数及E/A）进行对比及统计学分析。结果：治疗24个月末氨氯地平联合替米沙坦治疗高血压病的降压总有效率为96.0%,左室舒张末期内径、室间隔厚度、左室后壁舒张末期厚度、左室心肌重量指数均较治疗前明显下降,左室射血分数及E/A均较治疗前显著提高（P〈0.01）。结论：氨氯地平联合替米沙坦治疗高血压病伴左心室肥厚患者,能改善左心室收缩舒张功能,逆转左心室肥厚,有效控制高血压病患者的左室重构。

The treatment effects of amlodipine combined with telmisartan in elderly mild to moderate hypertensive patients complicated by left ventricular hypertrophy

Objective：To evaluate the treatment effects of amlodipine combined with telmisartan in elderly mild to moderate hypertensive patients complicated by left ventricular hypertrophy（LVH）.Methods 50 elderly mild to moderate hypertensive patients with LVH were treated by amlodipine combined with telmisartan.After 24 months blood pressure、left ventricular end diastolic dimension（LVDd）、thickness of interven tricular septum（IVSTd）、left ventricular posterior wall end diastole（LVPWTd）、left ventricular mass indexes（LVMI）、ejection fraction of left ventricle（EF）and E/A were contrasted and analyzed.Results：After 24-month treatment,blood pressure control rate reached 96.0,LVDd、IVSTd、LVPWTd and LVMI lowered more significantly,EF and E/A increased more significantly compared with pretreatment（P0.01）.Conclusion：The treatment of amlodipine combined with telmisartan in elderly mild to moderate hypertensive patients complicated by LVH can improve left ventricular diastolic function and reverse enlarged left ventricle