Nitric oxide promotes survival of cerebellar granule neurons cultured in vitro through the Akt pathway |
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| Authors: | Lin Wang Mei Li Lihua Zhou |
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| Institution: | Lin Wang1,Mei Li2,Lihua Zhou1 1Department of Anatomy,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China 2Department of Neurology,Second Affiliated Hospital,China |
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| Abstract: | In this study,cerebellar granule neurons were used to examine the role of nitric oxide on cell survival.The N-methyl-D-aspartic acid receptor antagonist,MK-801,and the soluble guanylate cyclase antagonist,1H-1,2,4]oxadiazolo-4,3-a] quinoxalin-1-one,decreased cell viability,induced caspase-3,and decreased phosphorylated-Akt levels,suggesting that blockade of nitric oxide production promotes apoptosis of differentiating cerebellar granule neurons.After administration of sodium nitroprusside,an endogenous ni... |
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| Keywords: | nitric oxide cerebellar granule neurons development apoptosis Akt cyclic guanosine monophosphate neural regeneration |
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