| L型结核分枝杆菌rpoB基因突变与利福平耐药性研究 |
| |
| 引用本文： | 刘丹,陈俊林,顾德林,曹文忠,陈晓丽. L型结核分枝杆菌rpoB基因突变与利福平耐药性研究[J]. 南通医学院学报, 2011, 31(6): 433-434 |
| |
| 作者姓名： | 刘丹 陈俊林 顾德林 曹文忠 陈晓丽 |
| |
| 作者单位： | 江苏省南通市第六人民医院结核科,南通,226013 |
| |
| 基金项目： | 南通市社会发展项目（S2009023） |
| |
| 摘 要： | 目的：探讨L型结核分枝杆菌rpoB基因突变与利福平耐药性的关系。方法：采用PCR和PCR-DS技术对23例初治肺结核和45例复治肺结核患者L型结核分枝杆菌临床分离株进行rpoB基因检测和序列分析。结果：初治肺结核L型结核分枝杆菌rpoB基因突变率为4.3%,复治肺结核耐L型结核分枝杆菌rpoB基因突变率为40.0%。结论：复治肺结核L型结核分枝杆菌rpoB基因突变率高于初治肺结核,L型菌rpoB基因突变是造成结核分枝杆菌形成利福平耐药性的主要机制。
|
| 关 键 词： | 结核分枝杆菌 细胞壁缺陷 rpoB基因 耐药性 |
Study the relationship of rpoB genes mutations and rifampin resistance of mycobacterial L forms |
| |
| LIU Dan,CHEN Junlin,GU Delin,CAO Wenzhong,CHEN Xiaoli. Study the relationship of rpoB genes mutations and rifampin resistance of mycobacterial L forms[J]. ACTA Academiae Medicinae Nantong, 2011, 31(6): 433-434 |
| |
| Authors: | LIU Dan CHEN Junlin GU Delin CAO Wenzhong CHEN Xiaoli |
| |
| Affiliation: | (Department of Tuberculosis Medical,Nantong Sixth People＇s Hospital,Nantong 226013) |
| |
| Abstract: | Objective： To study the relationship of gene mutation and rifampin resistance in L-forms of mycobacterium tuberculosis.Methods： rpoB genes mutation clinical isolated strains of mycobacterial L forms in 23 the first-treated patients and 45 second-treated patients were detected by PCR DS.Results： The rpoB gene mutation rate of first-treated patients and second-treated patients were 4.3% and 40.0% respectively.Conclusion： The rpoB genes mutation clinical isolated strains of mycobacterial L forms in second-treated patients was higher than that in first-treated patients and it was considered an important rifampin resistant mechanism of mycobacterium tuberculosis. |
| |
| Keywords: | mycobacterium tuberculosis cell wall deficient rpoB gene drug resistance |
| 本文献已被 维普 万方数据 等数据库收录！ |
