Antibody to collapsin response mediator protein 1 promotes neurite outgrowth from rat hippocampal neurons |
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| Authors: | Hongsheng Lin Jing Chen Wenbin Zhang Xiaobing Gong Biao Chen Guoqing Guo |
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| Affiliation: | Hongsheng Lin1,Jing Chen2,Wenbin Zhang1,2,Xiaobing Gong1,Biao Chen1,Guoqing Guo2 1Department of Orthopedics,the First Affiliated Hospital of Jinan University,Guangzhou 510630,Guangdong Province,China 2Department of Anatomy,Medical College of Jinan University,China |
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| Abstract: | This study examined the role of collapsin response mediator protein 1 (CRMP-1) on neurite outgrowth from rat hippocampal neurons by blocking its function using an antibody.Hippocampal neurons,cultured in vitro,were treated (blocked) using a polyclonal antibody to CRMP-1,and neurite outgrowth and cytoskeletal changes were captured using atomic force microscopy and laser confocal microscopy.Control cells,treated with normal rabbit IgG,established their characteristic morphology and had a large number of proce... |
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| Keywords: | collapsin response mediator protein 1 neuron microtubule neurite antibody block hippocampus rat neural regeneration |
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