Effect of sodium hydroxybutyrate in pain syndromes |
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| Authors: | E. I. Danilova V. N. Grafova R. U. Ostrovskaya V. K. Reshetnyak |
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| Affiliation: | (1) Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow;(2) Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | It is shown that sodium hydroxybutyrate exerts a preventive and therapeutic effect on models of neuropathic pain syndrome and adjuvant arthritis. The effects of sodium hydroxybutyrate droxybutyrate are correlated with its ability to reduce hyperactivity of the neurons that are generators of pathologically enhanced excitation and to inhibit the pathological algetic system. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 395–398, April, 1996 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences |
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| Keywords: | generator of pathologically enhanced excitation pathological algetic system neuropathic pain syndrome adjuvant arthritis |
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