| 苜蓿总皂苷提取物抗动脉粥样硬化和降血脂的实验研究 |
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| 引用本文： | 邴飞虹,程静,冯新刚,万敏,韩俊,李婧,廖一帆.苜蓿总皂苷提取物抗动脉粥样硬化和降血脂的实验研究[J].时珍国医国药,2010,21(3). |
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| 作者姓名： | 邴飞虹 程静 冯新刚 万敏 韩俊 李婧 廖一帆 |
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| 作者单位： | 1. 湖北中医学院,湖北,武汉,430065
2. 中国中医药科技开发交流中心,北京,100027 |
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| 摘 要： | 目的 观察苜蓿总皂苷提取物抗大鼠动脉粥样硬化和降血脂作用.方法 该实验采用高脂饲料、血管壁钙超载、内皮损伤三者结合引发大鼠大血管动脉粥样硬化斑块模型.检测指标:用紫外分光光度计测定血清总胆固醇TCH,甘油三酯(TG)和高密度脂蛋白(HDL-C)的含量;并计算低密度脂蛋白(LDL-C)的含量和动脉粥样硬化指数(AI);检测主动脉的病理变化.结果 苜蓿总皂苷提取物可明显降低高脂血症大鼠的血清TCH,TG,LDL-C水平,明显升高HDL-C水平,明显降低AI,与模型组比较有显著性差异(P< 0.05);主动脉斑块的病变分级,苜蓿总皂苷提取物明显降低粥样硬化面积,与模型组比较有显著性差异(P< 0.05).冠状动脉病变分级,苜蓿总皂苷提取物能明显降低AS病变发生率,减轻斑块对管腔的阻塞程度.结论 苜蓿总皂苷提取物具有降血脂和抗动脉粥样硬化的作用.
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| 关 键 词： | 苜蓿总皂苷提取物 大鼠 动脉粥样硬化 降血脂 |
Anti-atherosclerotic and Hypolipidemic Effects of Alfalfa Extract of Total Saponins in Rats |
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| BING Fei-hong,CHENG Jing,FENG Xin-gang,WAN Min,HAN Jun,LI Jing,LIAO Yi-fan.Anti-atherosclerotic and Hypolipidemic Effects of Alfalfa Extract of Total Saponins in Rats[J].Lishizhen Medicine and Materia Medica Research,2010,21(3). |
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| Authors: | BING Fei-hong CHENG Jing FENG Xin-gang WAN Min HAN Jun LI Jing LIAO Yi-fan |
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| Institution: | BING Fei-hong1,CHENG Jing1,FENG Xin-gang2,WAN Min1,HAN Jun1,LI Jing1,LIAO Yi-fan(1.Hubei College of Traditional Chinese Medical,Wuhan 430065,China,2.China Traditional Chinese Medicine Science , Technology Development Center,Beijing 100027,China) |
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| Abstract: | Objective To observe the anti-atherosclerotic and hypolipidemic effects in rats of alfalfa extract of total saponins.Methods The atherosclerosis model in rats was set up by high fat diet in combination with blood vessel wall calcium overload and endothelial injury.Blood-fat levels(TC,TG,LDL-C,HDL-C and AI)in serum were measured by ultraviolet spectrophotometer.The rats were sacrificed and the aorta,heart,liver and renal were collected for pathological changes.Results Alfalfa extract of total saponins could ... |
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| Keywords: | Total saponins of alfalfa extract Atherosclerosis Anti-atherosclerotic |
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