Clear CelI HepatocelIular Caxinoma with Abundant Myxoid Stroma |
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Authors: | Takeaki Fukuda Yoshihisa Ohnishi Yutaka Miyazaki Keizo Ohnuki Shinzo Tachikawa |
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Institution: | Second Department of Pathology, Niigata University School of Medicine, Niigata.;Departments of Internal Medicine, Tachikawa General Hospital, Nagaoka.;Departments of Pathology, Tachikawa General Hospital, Nagaoka. |
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Abstract: | A case of the clear cell variant of hepatocellular carcinoma with an abundant myxoid stroma is presented. The tumor occurred in a 55 year old Japanese man, and swelling of the scrotum was the initial symptom. The patient underwent high-level orchiectomy, and the pathologic diagnosis was a metastatic tumor on the surface of the processus vaginalis and intact testis. Extensive examination failed to show a primary site. Subsequent autopsy revealed a large hepatic tumor and metastatic nodules with a prominent myxoid appearance in multiple organs. Histological-ly, each tumor consisted of uniform small tumor cells with clear cytoplasm attributed to abundant accumulation of glycogen particles, and an abundant myxoid stroma was also present. The tumor cells were positive for keratin, α1– antitrypsin, α1-antichymotrypsin, liver ferritin, prealbumin, and fibrinogen, but lacked α fetoprotein. These findings indicated that this case was hepatocellular carcinoma of the clear cell type with a prominent myxoid stroma. Acta Pathol Jpn 42: 897–903, 1992. |
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Keywords: | Hepatocellular carcinoma Clear cell type Myxoid stroma |
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