| 脊髓谷氨酸转运体在神经病理性疼痛中的作用 |
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| 引用本文： | 孔明,胡兴国,曾因明. 脊髓谷氨酸转运体在神经病理性疼痛中的作用[J]. 实用疼痛学杂志, 2009, 5(1): 55-58. DOI: 10.3969/R.ISSN.1672-9633.2009.01.015 |
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| 作者姓名： | 孔明 胡兴国 曾因明 |
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| 作者单位： | 1. 江苏省麻醉医学研究所,江苏省麻醉学重点实验室,221002
2. 湖南省桃源县人民医院麻醉危重医学科,415700 |
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| 摘 要： | 谷氨酸是一种重要的兴奋性神经递质，通过作用于突触前膜和突触后膜的谷氨酸受体发挥作用。谷氨酸转运系统是灭活谷氨酸并维持谷氨酸内环境稳态的主要结构。最近的研究证实抑制脊髓谷氨酸转运体可减轻神经病理性疼痛，预示脊髓谷氨酸转运体可能是治疗神经病理性疼痛的靶点。本文就脊髓谷氨酸转运体在神经病理性疼痛中的作用及可能的机制作一综述。
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| 关 键 词： | 谷氨酸 转运体 神经病理性疼痛 脊髓 |
Role of the spinal glutamate transporter in neuropathic pain |
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| KONG Ming,HU Xing-guo,ZENG Yin-ming. Role of the spinal glutamate transporter in neuropathic pain[J]. Pain Clinic Journal, 2009, 5(1): 55-58. DOI: 10.3969/R.ISSN.1672-9633.2009.01.015 |
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| Authors: | KONG Ming HU Xing-guo ZENG Yin-ming |
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| Affiliation: | KONG Ming , HU Xing -guo , ZENG Yin -ming. (The Institute of Anesthesiology ＆ the Key Anesthesia Laboratory of Jiangsu Province, Xuzhou 221002, China. Department of Anesthesiology ＆ Critical Care Medicine , Taoyuan County People＇s Hospital. Hunan Province , Taoyuan 415700,China) |
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| Abstract: | Glutamate is an important excitatory neurotransmitter and acts on glutamate recep- tors located pre-and post-synaptic membranes. The glutamate transporter system is the primary mechanism for the inactivation of glutamate and the maintenance of glutamate homeostasis. Recent studies demonstrated that spinal glutamate transporter inhibitor can relieved neuropathic pain, suggesting that the spinal glutamate transporter might serve as a therapeutic target for treatment of neuropathic pain. This paper reviews the evidence for the role of the spinal glutamate transporter in neuropathie pain and discuss its potential mechanisms. |
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| Keywords: | Glutamate Transporter Neuropathic Pain Spinal Cord |
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