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Naltrexone blocks the effects of prenatal stress on sexual behavior differentiation in male rats |
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| Authors: | O B Ward E P Monaghan I L Ward |
| Affiliation: | 1. Pharmacobiology Department. Center of Research and Advanced Studies of IPN (CINVESTAV), México.;2. Medical and Psychology School, Autonomous University of Baja California, Tijuana, B.C., México.;1. Psychoneuroimmunology Laboratory, Graduate Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil;2. Núcleo de Pesquisas em Biodiversidade, Laboratório de Extração, Universidade Paulista - UNIP, Av. Paulista, 900, São Paulo, SP 01310-100, Brazil;3. School of Dentistry, Graduate Program in Health Sciences, University of Taubaté, Rua dos Operários, 9, Taubaté, SP 12020-340, Brazil |
| Abstract: | The male offspring of rats stressed three times daily during days 14-21 of pregnancy were more likely to show lordotic behavior when tested in adulthood than were control males. This feminization of sexual behavior was not observed if the mothers were injected with the opioid antagonist naltrexone before being stressed. These data suggest that endogenous opioids released under conditions of stress can alter the normal process of sexual behavior differentiation in the fetal male rat. |
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