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| 氟中毒人群过氧化氢酶和谷胱甘肽S-转移酶的活力 | |
| 引用本文： | 张婷,单可人,何燕,徐仕清,吴昌学,周曙光,李毅,王婵娟,赵艳,官志忠.氟中毒人群过氧化氢酶和谷胱甘肽S-转移酶的活力[J].贵阳医学院学报,2010,35(4):331-333. |
| 作者姓名： | 张婷 单可人 何燕 徐仕清 吴昌学 周曙光 李毅 王婵娟 赵艳 官志忠 |
| 作者单位： | 1. 贵阳医学院分子生物学重点实验室,贵州,贵阳,550004 2. 毕节市疾病预防控制中心,贵州,毕节,551700 3. 长顺县疾病预防控制中心,贵州,长顺,550700 |
| 基金项目： | 国家科技部国际合作项目，国家自然科学基金资助项目，贵州省长专项资金资助项目 |
| 摘 要： | 目的：探讨燃煤型氟中毒地区人群过氧化氢酶（CAT）、谷胱甘肽S-转移酶（GSTs）活力与氧化应激的关系。方法：于贵州省毕节市鸭池镇燃煤型氟中毒非改灶村抽取245名村民作为非干预组,于该市长春镇燃煤型氟中毒改灶村抽取240名村民作为干预组,于非地方性氟中毒长顺县白云山镇抽取247名村民作对照组,利用比色法分别测定CAT、GSTs的活力。结果：非干预组血浆CAT活力和GSTs活力低于干预组和对照组,干预组低于对照组,各组间差异有统计学意义（P〈0.05）;各组间CAT、GSTs活力无性别差异（P〉0.05）。结论：过量氟可能使体内自由基代谢失衡,推测通过人为干预氟的摄入,有助于机体恢复氧化平衡。 |
| 关 键 词： | 氟化物中毒 过氧化氢酶 谷胱甘肽转移酶 氧化性应激 |
Activities of Catalase and Glutathione S-Transferase in Fluorosis Patients |
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| ZHANG Ting,SHAN Keren,HE Yan,XU Shiqing,WU Changxue,ZHOU Shuguang,LI Yi,WANG Chanjuan,ZHAO Yan,GUAN Zhizhong.Activities of Catalase and Glutathione S-Transferase in Fluorosis Patients[J].Journal of Guiyang Medical College,2010,35(4):331-333. | |
| Authors: | ZHANG Ting SHAN Keren HE Yan XU Shiqing WU Changxue ZHOU Shuguang LI Yi WANG Chanjuan ZHAO Yan GUAN Zhizhong |
| Institution: | 1.The Key Lab of Molecular Biology,Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Center for Disease Prevention and Control of Bijie,Bijie 551700,Guizhou,China;3.Center for Disease Prevention and Control of Changshun County,Changshun 550700,Guizhou,China) |
| Abstract: | Objective： To investigate the relationship of plasma catalase（CAT） and glutathione S-transferase（GSTs） activity levels with oxidation stress in patients with coal-burning caused fluorosis.Methods： 245 villagers that use unchanged stoves in coal-burning fluorosis area were selected as non-intervention group（group N）,240 villagers using improved stoves in fluorosis endemic area were chosen as intervention group（group I）,and 247 villagers in non-fluorosis-endemic area were as control group（group C）.The activities of CAT and GSTs of them were tested with Spectrophotometer.Results： The activities of plasma CAT and GSTs of group N were significantly lower than those of group I（P0.05）,and the latter ones were significantly lower than those of group C（P0.05）.No significant difference of the two enzymes based on sex was found in all the 3 groups.Conclusion： Excessive intaking of fluorin might cause unbalance of free radical metabolism,and artificial intervention of fluorin intaking could help to recover the balance of oxidation. |
| Keywords: | fluoride poisoning catalase glutathione transferase oxidative stress |
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