神经氨酸苷酶抑制剂Siastatin B的全合成及其绝对构型的推定 |
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引用本文: | 西村吉雄,王文梅.神经氨酸苷酶抑制剂Siastatin B的全合成及其绝对构型的推定[J].中国医药工业杂志,1989,20(7):307-313. |
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作者姓名: | 西村吉雄 王文梅 |
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作者单位: | 东京微生物化学研究所,上海医药工业研究院 日本,中国 |
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摘 要: | 以L-核糖原料经20余步反应全合成了神经氨酸苷酶抑制Siastatin B(1),并根据其具有与天然产物同样的生物活性,推定它的绝对构型系1b。
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关 键 词: | SiastatinB 合成 构型 哌啶 抑制剂 |
TOTAL SYNTHESIS AND ABSOLUTE CONFIGURATION OF SIASTATIN B,NEURAMINIDASE INHIBITOR |
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Authors: | Yoshio Nishimura WANG Wen-Mei Shinichi Kondo Takaaki Aoyagi Hamao Umezawa |
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Abstract: | Siastatin B(1).apotent neuraminidase inhibitor was totallysynthesized via over 20 steps of reaction from L-ribose as a starting material.The synthetic 1 showed the some bioactivity as the natural one, it was provedthat the absolute configuration of 1 was 2R-acetamido-3R, 4S-dihydroxypiperidine-5S-carboxylic acid (1b). |
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Keywords: | neuraminidase inhibitor Siastatin B total synthesis absolute configuration |
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