两种药物治疗新诊断癫痫的安全性与疗效对比分析

目的:探讨应用两种药物治疗新诊断癫痫的安全性与疗效。方法:癫痫患儿60例根据入院顺序平分为两组:治疗组与对照组各30例,对照组采用托吡酯治疗,治疗组采用拉莫三嗪治疗,所有患者均用韦氏成人智力量表中国修订版(WAIS-CR)和蒙特利尔认知评分量表(M0CA)在用药前及用药后3个月进行问卷评定。结果:治疗组治疗后与治疗前相比,言语智商、操作智和总智商明显下降(P<0.05),而对照组治疗前后上述指标改善不大(P<0.05)。治疗组治疗后与治疗前相比M0CA评分明显上升(P<0.05),而对照组治疗前后上述指标改善不大(P<0.05)。结论:与常规托吡酯预防新诊断癫痫相比,拉莫三嗪对能够更好的恢复认知功能,可提高冶疗疗效,同时安全性好。

Comparative Analysis of Safety and Effect of Treating Newly Diagnosed Epilepsy by Topiramate and Lamotrigine

Objective:To explore safety and effect of treating newly diagnosed epilepsy by topiramate and lamotrigine.Methods: 60 children with epilepsy were equally divided into Treatment Group and Control Group(each 30 cases) as per admission sequence. Control Group was treated with topiramate;on the other hand,Treatment Group was treated with lamotrigine.All the patients were assessed by questionnaire as per WAIS-CR and MOCA 3 months before and after drug treatment.Results:Before and after treatment,Treatment Group showed a significant decrease in language,operation and total intelligence(P<0.05);however,Control Group showed no significant increase in the above indexes(P<0.05).Moreover,before and after treatment,Treatment Group had a significant increase in MOCA score (P<0.05);however,Control Group showed no significant increase in the above indexes.Conclusion:Compared with via topiramate for treating newly diagnosed epilepsy,lamotrigine has a better function of restoring cognition to improve curative effect and has good safety.