充血性心力衰竭患者甲状腺激素及心功能改变的临床研究

目的:探讨充血性心力衰竭(CHF)患者甲状腺激素(TH)变化和心功能的关系。方法:用放射免疫法分别测定CHF患者36例(CHF组)和健康对照组23例(对照组)血清三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、反三碘甲状腺原氨酸(rT3)及促甲状腺素(TSH),用超声心动图测定心排血量(CO)、左室射血分数(LVEF)、左室舒张末容积(LVEDV)、左室收缩末容积(LVESV)。结果:CHF组T3水平和LVEF、CO明显低于对照组,rT3和LVEDV、LVESV显著升高,且随着心力衰竭程度加重,其变化越明显。结论:TH变化对CHF患者心功能损害程度、治疗及预后具有重要意义。

Clinical Study of the Relationship between Thyroid Hormone Changes and Cardiac Function in CHF Patients

Objective:To explore the relationship between thyroid hormone(TH) changes and cardiac function in patients with congestive heart failure(CHF).Methods:In CHF group(36 patients with CHF) and control group(23 non-CHF patients),three plasma triiodothyronine(T3),four-triiodothyronine(T4),thyroid iodine against three the original acid(rT3) and thyroid stimulating hormone (TSH) were determinated by radioimmunoassay,measured cardiac output(CO),left ventricular ejection fraction(LVEF),left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV) by echocardiography,Results:In CHF group T3 levels and LVEF,CO was significantly lower than the control group,rT3,and LVEDV,LVESV increased significa(?)tly,and with the degree of heart failure increased,the more obvious cbanges.Conclusions:In patients with CHF,TH changes has great significance on cardiac function damage,treatment and prognosis.