糖尿病肾病患者血清胱抑素C检测的临床意义

目的:探讨血清胱抑素C(Cys-C)在糖尿病肾病患者中检测的临床意义。方法根据尿微量白蛋白排泄率将104例糖尿病肾病患者分为A(45例)、B(31例)、C(28例)三组,清晨空腹抽取糖尿病患组和对照组静脉血3m1,检测Cys-C、2-MG、BUN、Cr浓度,并将结果与正常对照组(35例)比较分析。结果A组Cys-C检测结果为(0.78±0.67)mg/l高于对照组(0.51±0.12)mg/l,差异具有统计学意义(P<0.05),2-MG、BUN、Cr三种指标都有所升高,但与对照组相比差异不具有统计学意义(P>0.05),随着病情增加B组与C组四项指标浓度都升高,且B组高于A组,C组高于B组,组间比较差异均具有统计学意义(P<0.01)。结论Cys-C是一种反映肾小球滤过率变化的理想的内源性标志物,对糖尿病肾病的早期诊断起着重要的作用。

The Clinical Significance of Serum Cystatin C Measured In Patients With Diabetic Nephropathy

Objective:To explore the clinical significance of serum Cys-C measured in the patients with diabetic nephropathy. Method:According to the UAER level,104 patients with diabetic nephropathy were separated into three groups which were A group(45),B group(31) and C group(28),fasting serum Cys-C,2-MG,BUN,Cr levels were measured as well as the normal control group.Result: The Cys-c level of A group was(0.78±0.67)mg/l which was significantly higher than the level of the normal control group which was (0.51±0.12)mg/l(P<0.05).2-MG,BUN and Cr levels of B and C groups were all increased too,but were not apparently higher than normal control group(P>0.05).Along with the aggravation of the disease,Cys-C,2-MG,BUN and Cr levels were increased in B and C groups,and all the difference have statistics significance(P<0.01).Conclusion:Cys-C is an ideal endogenous marker in the reflection of changes of glomerular filtration rate,which plays an important role in the early diagnosis of diabetic nephropathy.