Bmi-1及端粒酶在宫颈癌变过程中的表达及意义

目的:探讨Bmi-1、端粒酶蛋白在正常宫颈、癌前病变、子宫颈癌中的表达及其与临床病理特征的关系。方法:采用免疫组化(SP)方法对20例正常宫颈、50例宫颈上皮内瘤变(CN)、35例宫颈癌中的Bmi-1、端粒酶蛋白表达情况进行检测。结果:在正常宫颈、宫颈上皮内瘤变、宫颈癌中,Bmi-1的表达率依次增高,端粒酶的表达率也能依次增高,均有统计学意义(P<0.05)。Bmi-1和端粒酶的表达与年龄、有无淋巴结转移无关,和临床分期有关(P<0.05)。宫颈癌组织中的Bmi-1和端粒酶蛋白明显高于癌旁组织(P值分别为0.004,0.000)。结论:联合检测Bmi-1和端粒酶的表达水平,一定程度上揭示它们与宫颈癌发生发展的关系,同时可以显示宫颈上皮内瘤变向宫颈癌转变的潜能。

The Expression and Significance of Bmi-1 and Telomerase in Cervical Transformation Process

Objective:Of Bmi-1,telomerase protein in normal cervix,precancerous lesions,cervical carcinoma and its relationship with clinicopathological fearures.Methods:Immunohistochemistry(SP) method in 20 cases of normal cervix.50 cases of cervical intraepithelial neoplasia(CN),35 cases of cervical cancer in the Bmi-1,telomerase protein expression were detected.Results:In normal cervix,cervical intraepithelial neoplasia,cervical cancer,Bmi-1 expression rates were increased telomerase expression can be increased in turn,were statistically significant(P<0.05).Bmi-1 and telomerase expression with age,lymph node metastasis and clinical stage (P<0.05),Cervical cancer and telomerase protein Bmi-1 was significantly higher than the adjacent tissue(P values were 0.004,0.000). Conclusion:Joint detection of Bmi-1 expression and telomerase,to a certain extent they reveal the relationship between the development of cervical cancer,and can show cervical intraepithelial neoplasia to cervical cancer transformation potential.