| 新藤黄酸固体脂质纳米粒的制备与质量评价 |
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| 引用本文： | 陈延杰,陈卫东. 新藤黄酸固体脂质纳米粒的制备与质量评价[J]. 中国药业, 2011, 20(21): 36-38 |
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| 作者姓名： | 陈延杰 陈卫东 |
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| 作者单位： | 安徽中医学院药学院,安徽合肥,230038 |
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| 摘 要： | 目的制备新藤黄酸固体脂质纳米粒并进行质量考察。方法采用正交试验设计优化处方,以高温乳化-低温固化的方法制备新藤黄酸固体脂质纳米粒。并对其包封率、形态等进行研究。结果所制得的新藤黄酸固体脂质纳米粒外观形态圆整,粒度分布均匀,平均粒径为163.3 nm,包封率为(60.1±1.1)%。结论高温乳化-低温固化的方法适用于新藤黄酸-固体脂质纳米粒的制备。
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| 关 键 词： | 新藤黄酸 固体脂质纳米粒 高温乳化-低温固化 |
Preparation and Evaluation of Gambogenic Acid Solid Lipid Nanoparticles |
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| Chen Yanjie,Chen Weidong. Preparation and Evaluation of Gambogenic Acid Solid Lipid Nanoparticles[J]. China Pharmaceuticals, 2011, 20(21): 36-38 |
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| Authors: | Chen Yanjie Chen Weidong |
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| Affiliation: | Chen Yanjie,Chen Weidong(Anhui University of Traditional Chinese Medicine,Hefei,Anhui,China 230038) |
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| Abstract: | Objective To investigate the preparation and evaluation of gambogenic acid solid lipid nanoparticles.Methods The formulation was optimized through orthogonal design.Gambogenic acid solid lipid nanoparticles were prepared by the method of emulsification evaporation-solidification at low temperature.The encapsulation efficiency and appearance of solid lipid nanoparticles were studied.Results The mean particle size was found to be 163.3 nm with a narrow particles distribution of polydispersity index.The drug e... |
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| Keywords: | gambogenic acid solid lipid nanoparticles emulsification evaporation-solidification at low temperature |
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