| 细胞自噬在病原体感染过程中的作用研究进展 |
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| 引用本文： | 章晟,于长明,殷瑛,陈薇. 细胞自噬在病原体感染过程中的作用研究进展[J]. 军事医学科学院院刊, 2009, 33(5): 469-472 |
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| 作者姓名： | 章晟 于长明 殷瑛 陈薇 |
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| 作者单位： | 军事医学科学院微生物流行病研究所病原微生物与生物安全国家重点实验室,北京,100071 |
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| 摘 要： | 细胞自噬是一种通过降解蛋白质和细胞器维持细胞内平衡的细胞机制。细胞自噬具有很多重要的生理功能,包括清除病原体的感染。但是由于细胞自噬在进化过程中具有高度的保守性,某些病原体通过进化,具有逃避细胞自噬的能力,甚至利用细胞自噬为病原体复制和发育提供有利条件。本文综述了细胞自噬与病原体相互作用的研究进展。
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| 关 键 词： | 细胞自噬 病原体 细胞自噬相关基因 |
Research progress of the role of autophagy in infectious diseases |
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| ZHANG Sheng,YU Chang-Ming,YIN Ying,CHEN Wei. Research progress of the role of autophagy in infectious diseases[J]. Bulletin of the Academy of Military Medical Sciences, 2009, 33(5): 469-472 |
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| Authors: | ZHANG Sheng YU Chang-Ming YIN Ying CHEN Wei |
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| Affiliation: | ( State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China) |
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| Abstract: | Autophagy regulates the intracellular homeostatic mechanism that mediates the degradation of proteins and organelles. Autophagy plays a number of roles in various cellular physiological functions, involving intracellular pathogens clearance. Since autophagy is highly conserved, some pathogens have evolved to evade autophagy utilizing different strategies. This article mainly reviews the function of autophagy in pathogens. |
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| Keywords: | autophagy pathogen autophagy related gene |
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