右旋美托咪啶对七氟醚复合瑞芬太尼麻醉期间麻醉深度的影响

目的：观察吸入七氟醚复合瑞芬太尼麻醉期间，右旋美托嘧啶对脑电双频谱指数（ BIS）的影响。方法选取行全麻乳腺改良根治手术的患者28例，咪达唑仑0.05 mg/kg、丙泊酚2 mg/kg和芬太尼2μg/kg麻醉诱导，患者失去意识后静脉推注罗库溴铵0.6μg/kg，肌松完全后行气管内插管，吸入七氟醚，泵注瑞芬太尼2μg/kg维持麻醉。将28例患者分成观察组与对照组，脑电双频谱指数（ BIS ）稳定后观察组患者给予静脉推注0.4μg/kg右旋美托嘧啶与生理盐水稀释的5 ml药物，而对照组患者静脉推注5 m1的生理盐水。对两组患者入室后、给药前、给药后5、10、15、30 min脑电双频谱指数（ BIS）的变化进行对比性分析。结果观察组患者脑电双频谱指数逐步下降，30min时下降至（41.6＆#177;5.1）。而对照组患者脑电双频谱指数无明显变化。结论七氟醚复合瑞芬太尼麻醉期间应用右旋美托嘧啶药物，有助于降低脑电双频谱指数，增加麻醉深度。

Effects of dexmedetomidine on the depth of anesthesia during sevoflrane combined with remifentanil

Objective To observere the effect of dexmedetomidine on the depth of anesthesia during sevoflrane combined with remifentanil .Methods Twenty-eight AS-AⅠ~Ⅱfemal patients with breast cancer , scheduled for radical mammotomy , were random-ly assigned to receive sevoflrane inhalation combined with remifentanil anesthesia .Anesthes-ia was induced with midazolam 0.05 mg/kg,fentanyl 2 μg/kg and propofol 2 mg/kg.T-racheal intubation was facilitated with rocuronium 0.6 mg/kg.Brain electrical double spectrum index （BIS） of all the patients were observed , After the BIS was maitained for （50 ＆#177;5）, patients were randomly di-vided into observation group and control group , the observa-tion group patients give 0.4 μg/kg dexmedetomi-dine saline dilution 5 ml, and control gro-up patients were given 5 ml of saline.The BIS of entering operating room, beforegiving dexmedetomidine and after giving dexmedetomidine 5,10,15,30 min were recorded.Re-sults After inducing , the BIS of the two groups were decline ,after giving dexmedetomidi-ne, the BIS of observa-tion group patients was decone continuly ,but the BIS of control group did not altered obviously .Conclusion During sevoflrane combined with remifentanil anesthesia , giving dexmedetomidine can reduce electrical double spectrum index ,inhence de-pth of anesthesia .