Is irritable bowel syndrome an organic disorder? |
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作者姓名: | Magdy El-Salhy Doris Gundersen Odd Helge Gilja Jan Gunnar Hatlebakk Trygve Hausken |
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作者单位: | Section for Gastroenterology,Department of Medicine,Stord Helse-Fonna Hospital,5409 Stord,Norway;Section for Gastroenterology,Department of Clinical Medicine,University of Bergen 5006 Bergen,Norway;Department of Research,Helse-Fonna,5528 Haugesund,Norway |
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基金项目: | Supported by A grant from Helse-Fonna |
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摘 要: | Irritable bowel syndrome(IBS)is a common gastrointestinal disorder that is generally considered to be functional because there appears to be no associated anatomical defect.Stress and psychological factors are thought to play an important role in IBS.The gut neuroendocrine system(NES),which regulates all functions of the gastrointestinal tract,consists of endocrine cells that are scattered among the epithelial cells of the mucosa,and the enteric nervous system.Although it is capable of operating independently from the centra nervous system(CNS),the gut NES is connected to and modulated by the CNS.This review presents evidence for the presence of an anatomical defect in IBS patients,namely in the gastrointestinal endocrine cells.These cells have specialized microvilli that project into the lumen and function as sensors for the luminal content and respond to luminal stimuli by releasing hormones into the lamina propria,which starts a chain reaction that progresses throughout the entire NES.The changes in the gastrointestinal endocrine cells observed in IBS patients are highly consistent with the other abnormalities reported in IBS patients,such as visceral hypersensitivity,dysmotility,and abnormal secretion.
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关 键 词: | Cholecystokinin Dysmotility Endocrine cells Enteric nervous system Ghrelin Peptide YY Secretion Secretin Serotonin Visceral hypersensitivity |
收稿时间: | 2013-09-27 |
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