硫酸钙载庆大霉素植入材料研究

采用凝结成型法制备了硫酸钙载硫酸庆大霉素植入材料GSCS,并用分光光度法研究了在体外模拟条件下庆大霉素的释放规律及载体材料硫酸钙的吸收速率,比较了两种不同载药方式GSCS的庆大霉素释放速率。不同庆大霉素含量试样的日失重率变化趋势与纯硫酸钙试样相同,说明庆大霉素含量对硫酸钙吸收规律影响不大。庆大霉素的释放主要受硫酸钙溶蚀的控制,因此不同庆大霉素含量GSCS具有相同的释放规律。日释放率(DRP)大小顺序在前期大致为ED>CO,而释放后期恰好相反。采用兔桡骨缺损模型初步探索了GSCS作为植入材料的可能性,术后14周大部分缺损部位已经长出新骨。

Studies on the GS Impregnated Calcium Sulfate Implants

The gentamicin sulfate carried calcium sulfate (GSCS) implants were fabricated by the coagulating method, and the release rate of the gentamicin tested by UV-spectrometer and the absorbing rate of the calcium sulfate carrier in vitro were studied. The release patterns of two types of GSCS were compared. The trend of daily weight loss of GSCS was found being similar to that of pure calcium sulfate, which suggested that the gentamicin part has little effect on the absorbing pattern of calcium sulfate. The release rate of gentamicin is controlled by the erosion rate of calcium sulfate, so GSCS with different amount of gentamicin has the same release patterns. The DRP value of ED is higher than that of CO during the early stage, while the DRP value of ED is lower than that of CO during the late stage. The GSCS samples were implanted into the defect mold on the radii of the rabbits to investigate the potential for the use of GSCS implants as bone fillers, and the results revealed that new bone had been induced in a great part of the defect at 14 weeks after operation.