Synthesis, stereochemistry, and biological properties of the depigmenting agents, melanostatin, feldamycin and analogs. |
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| Authors: | K Imae H Kamachi H Yamashita T Okita S Okuyama T Tsuno T Yamasaki Y Sawada M Ohbayashi T Naito |
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| Affiliation: | Bristol-Myers Squibb Research Institute, Tokyo, Japan. |
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| Abstract: | Syntheses of melanostatin and feldamycin have been completed from L-serine and L-threonine, respectively, and the configuration of unknown asymmetric carbons determined. Feldamycin analogs have also been prepared and the L-tryptophyl analog was the most potent in the depigmentation of Streptomyces bikiniensis and B16 melanoma cells. |
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