持续腹腔热灌注化疗治疗中晚期消化道肿瘤临床研究

目的 :探讨持续腹腔热灌注化疗对中晚期消化道肿瘤的治疗效果。方法 :将 6 0例中晚期消化道肿瘤患者随机分为化疗组 2 9例 (对照组 ) ,持续腹腔热灌注化疗 (CHPP)组 31例 (热化疗组 )。结果 :热疗组有效率 (6 7.7% )高于对照组 (4 1.3% ) ,具有显著性差异 (P <0 .0 5 )。热疗组腹水减少有效率 (7/ 9)较对照组 (4 / 8)高。毒副反应两组无显著性差异 (P >0 .0 5 )。结论 :在中晚期消化道肿瘤 ,尤其伴有腹水病人治疗中 ,采用持续腹腔热灌注化疗可明显提高治疗效果。

Comparative study on CHPP on patients with late digestive tract cancer

Objective: To study the CHPP of treatment of metastasis of late digestice tract cancer.Methods:60 patients with late digestive tract cancer were divided into two groups.One group(rerence group) of patients 29 cases were underwent chemotherapeutic treatment while another(treatment group) 31 cases were treated by CHPP. Results:Through CHPP(treatmentgroup) the treatment show effectiveness as much 67.7% higher than that of reference group as 41.3%. This indicates the fact that there were significant differences between the groups(p<0.05).The effectiveness of decrease on ascites is 88.9% with the treatment group while 50% with the reference group, indicating a positive difference between the groups(p<0.01). There were no sharp difference in the side-effects and poisonous effects between the two groups(p>0.05) .Conclusions: CHPP on patients with late digestive tract cancer, especially those patients followed by ascites,can evidently enhance the effectiveness of the treatment.