| 卵巢肿瘤患者外周血乙酰肝素酶测定及临床意义 |
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| 引用本文： | 韦露薇,李力,张玮,潘忠勉,姚德生,张洁清. 卵巢肿瘤患者外周血乙酰肝素酶测定及临床意义[J]. 实用妇产科杂志, 2011, 27(10) |
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| 作者姓名： | 韦露薇 李力 张玮 潘忠勉 姚德生 张洁清 |
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| 作者单位： | 1. 广西柳州市工人医院
2. 广西医科大学附属肿瘤医院,广西南宁,530021 |
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| 摘 要： | 目的:探讨卵巢肿瘤患者外周血乙酰肝素酶(Hpa)含量测定的临床价值。方法:选择经病理学检查确诊的卵巢肿瘤,采用酶联免疫吸附法(ELISA)检测51例卵巢恶性肿瘤患者血清标本,其中未接受治疗26例(恶性治疗前组)、术后16例(恶性术后组)、复发9例(复发组);17例卵巢良性肿瘤(良性组)及16例正常妇女(对照组)血清中Hpa的表达。并将其与患者临床病理关系及预后进行分析。结果:①恶性治疗前组血清中Hpa含量(39.00±7.26μg/L)显著高于良性组(32.36±6.17μg/L)及对照组(26.22±8.06μg/L),差异有高度统计学意义(P<0.01);复发组、恶性术后组血清中Hpa含量(35.89±4.48μg/L,33.85±6.96μg/L)均高于对照组,差异均有高度统计学意义(P<0.01),与良性组差异均无统计学意义(P>0.05)。卵巢恶性肿瘤患者术后血清Hpa含量明显低于术前(31.58±5.67μg/L与38.02±7.74μg/L),差异有统计学意义(P<0.05)。②卵巢恶性肿瘤患者血清Hpa含量与肿瘤的临床分期、组织学分化程度、腹水量和有无肝转移相关(P<0.05)。③ROC曲线H...
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| 关 键 词： | 卵巢 肿瘤 乙酰肝素酶 |
Detection and Clinical Significance of Serum Heparanase in Malignant Ovarian Tumor |
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| WEI Luwei,LI Li,ZHANG Wei,et al. Detection and Clinical Significance of Serum Heparanase in Malignant Ovarian Tumor[J]. Journal of Practical Obstetrics and Gynecology, 2011, 27(10) |
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| Authors: | WEI Luwei LI Li ZHANG Wei et al |
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| Affiliation: | WEI Luwei,LI Li,ZHANG Wei,et al(Tumor Hospital,Guangxi Medical University,Nanning Guangxi 530021,China) |
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| Abstract: | Objective:To explore the clinical significance of serum heparanase(Hpa) detection in patients with malignant ovarian tumors.Methods:The serum heparanase(Hpa) was detected by enzyme-linked immunosorbent assay in 51 cases of ovarian cancers confirmed by pathology,in which 26 cases were without any treatment(malignant preoperation) ,16 cases were after operation(malignant postoperation) ,9 cases were recurrence(recurrence group) ,17 cases were with ovarian benign tumors(begin group) and 16 cases were normal co... |
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| Keywords: | Ovarian Cancer Heparanase |
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