| 妊娠时机对妊娠合并系统性红斑狼疮病情及妊娠结局的影响 |
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| 引用本文： | 尹玉竹,周水生,吴玲玲,黄建林,张培珍.妊娠时机对妊娠合并系统性红斑狼疮病情及妊娠结局的影响[J].实用妇产科杂志,2011,27(12). |
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| 作者姓名： | 尹玉竹 周水生 吴玲玲 黄建林 张培珍 |
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| 作者单位： | 中山大学附属第三医院,广东广州,510630 |
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| 摘 要： | 目的:探讨妊娠时机对妊娠合并系统性红斑狼疮(SLE)患者孕期病情及妊娠结局的影响.方法:对46例妊娠合并SLE孕妇的临床资料进行回顾性分析,按妊娠时机的不同分为两组:SLE控制期和缓解期达6个月以上怀孕者为指导性妊娠组(32例)；SLE活动期怀孕者以及孕期新发SLE的病例为非指导性妊娠组(14例),比较两组患者孕期SLE的病情和妊娠结局的不同.结果:①指导性妊娠组孕期SLE的活动率和泼尼松用量分别为15.6％和9.6±1.1 mg/d明显低于非指导性妊娠组100％和24.1±18.2 mg/d(P =0.000,P=0.012).②指导性妊娠组24小时尿蛋白定量、肌酐、抗dsDNA抗体等指标的异常率均较非指导性妊娠组明显降低(P=0.003,P=0.004,P=0.021).③指导性妊娠组无一例母婴死亡；非指导性妊娠组产妇死亡1例,胎儿丢失5例.指导性妊娠组的活产率(100％)较非指导性妊娠组(64.3％)明显升高(P=0.001)；胎儿丢失和胎儿生长受限发生率分别为0和18.8％,较非指导性妊娠组35.7％和50.0％明显降低(P=0.001,P=0.030).结论:妊娠时机对妊娠合并SLE患者孕期是否出现狼疮活动以及妊娠结局,尤其是胎儿结局影响较大,选择在SLE病情稳定半年以上计划怀孕,妊娠结局较好.
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| 关 键 词： | 妊娠 时机 系统性红斑狼疮 妊娠结局 泼尼松 |
Influence of Conception Timing on Lupus Flares and Pregnancy Outcomes in Pregnant Women with Systemic Lupus Erythematosus |
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| YIN Yuzhu,ZHOU Shuisheng,WU Lingling,et al.Influence of Conception Timing on Lupus Flares and Pregnancy Outcomes in Pregnant Women with Systemic Lupus Erythematosus[J].Journal of Practical Obstetrics and Gynecology,2011,27(12). |
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| Authors: | YIN Yuzhu ZHOU Shuisheng WU Lingling |
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| Institution: | YIN Yuzhu,ZHOU Shuisheng,WU Lingling,et al (Third Affiliated Hospital,Sun Yat-sen University,Guangzhou Guangdong 510630,China) |
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| Abstract: | Objective:To explore the influence of conception timing on lupus flares and pregnancy outcomes in pregnant women with systemic lupus erythematosus (SLE).Methods:The clinical data of 46 pregnant women with SLE were retrospectively analyzed. According to the different conception timing, 46 gravidas with SLE were divided into two groups: 32 patients who had controlled SLE and remission duration over 6 months before conception belonged to guidance pregnant group. Active lupus disease before conception and new o... |
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| Keywords: | Conception Timing Systemic lupus erythematosus Pregnancy outcome Prednisone |
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