| 重度子痫前期患者的血浆代谢组学研究 |
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| 引用本文： | 罗雪梅,王晨虹,刘大艳.重度子痫前期患者的血浆代谢组学研究[J].实用妇产科杂志,2011,27(12). |
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| 作者姓名： | 罗雪梅 王晨虹 刘大艳 |
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| 作者单位： | 南方医科大学附属深圳市妇幼保健院,广东深圳,518028 |
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| 摘 要： | 目的:探讨重度子痫前期患者血浆的代谢组变化及代谢组学技术早期诊断重度子痫前期的应用价值.方法:采用基于高效液相色谱-3200 Q trap质谱的代谢组学方法,检测51例重度子痫前期患者和45例正常妊娠妇女血浆代谢组的变化,运用模式识别方法分析数据.结果:51例重度子痫前期患者和45例正常妊娠妇女经代谢组学方法得到很好的区分,并找到相对应的16个潜在的生物标记物,其中浓度呈下降趋势的代谢小分子有峰89、95、98、118、135、157、187、191、215、240,浓度呈上升趋势的有峰139、155、284、451、837、922.结论:建立的代谢组学方法可以区分重度子痫前期和正常妊娠,综合代谢标记物变化趋势构成重度子痫前期的代谢特征,其对早期诊断重度子痫前期有很好的前景.
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| 关 键 词： | 子痫前期 代谢组学 生物标记物 高效液相色谱串联质谱 |
Plasma Metabonomics in Severe Pre-eclampsia |
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| LUO Xuemei
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WANG Chenhong
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LIU Dayan.Plasma Metabonomics in Severe Pre-eclampsia[J].Journal of Practical Obstetrics and Gynecology,2011,27(12). |
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| Authors: | LUO Xuemei WANG Chenhong LIU Dayan |
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| Institution: | LUO Xuemei,WANG Chenhong,LIU Dayan (Shenzhen Maternity and Child Healthcare Hospital,Southern Medical University,Shenzhen Guangdong 518028,China) |
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| Abstract: | Objective:To investigate the plasma metabolomic changes in severe pre-eclampsia and the value of metabolomic technology in early detection and diagnosis of severe pre-eclampsia.Methods:High performance liquid chromatography tandem 3200 Q trap mass spectrometry was performed on 51 plasma samples from women with severe pre-eclampsia and 45 normal control. Data-processing was normalized by software. Pattern recognition was employed for analysis.Results:51 women with severe pre-eclampsia and 45 normal control w... |
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| Keywords: | Pre-eclampsia Metabonomics Biomarkers High performance liquid chromatography tandem mass spectrometry |
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