| 乳腺癌组织中CD44v6和MMP-2的表达及其与淋巴结转移的关系 |
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| 引用本文： | 王秀清,刘惠民,赵琰龙,时志民.乳腺癌组织中CD44v6和MMP-2的表达及其与淋巴结转移的关系[J].现代肿瘤医学,2011,19(2):272-273. |
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| 作者姓名： | 王秀清 刘惠民 赵琰龙 时志民 |
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| 作者单位： | 河北工程大学附属医院病理科,河北,邯郸,056002 |
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| 基金项目： | 邯郸市科技局重点资助项目(编号:0923108059) |
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| 摘 要： | 目的:检测CD44v6、MMP-2在乳腺浸润性导管癌中的表达情况,探讨它们与淋巴结转移的关系。方法:采用免疫组化SP法检测100例乳腺浸润性导管癌中CD44v6、MMP-2的表达情况。结果:CD44v6蛋白在正常乳腺组织及乳腺浸润性导管癌中的阳性表达率分别为12.5%(5/40)、87%(87/100),CD44v6在淋巴结转移组中的阳性表达率(56/60)明显高于无淋巴结转移组(P<0.05)。MMP-2蛋白在正常乳腺组织及乳腺浸润性导管癌中的阳性表达率分别为0(0/40)、94%(94/100),MMP-2在淋巴结转移组中的阳性表达率(59/60)明显高于无淋巴结转移组(P<0.05)。结论:CD44v6、MMP-2蛋白在乳腺浸润性导管癌组织高表达,且均与淋巴结转移有关(P<0.05),联合检测CD44v6与MMP-2有助于综合判断乳腺浸润性导管癌的恶性程度和转移潜能。
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| 关 键 词： | 浸润性导管癌 CD44v6 MMP-2 转移 |
Relationship between the expression of CD44v6 and MMP-2 in breast carcinoma and lymph node metastasis |
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| WANG Xiu-qing,LIU Hui-min,ZHAO Yan-long,SHI Zhi-min.Relationship between the expression of CD44v6 and MMP-2 in breast carcinoma and lymph node metastasis[J].Journal of Modern Oncology,2011,19(2):272-273. |
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| Authors: | WANG Xiu-qing LIU Hui-min ZHAO Yan-long SHI Zhi-min |
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| Institution: | WANG Xiu-qing,LIU Hui-min,ZHAO Yan-long,SHI Zhi-min Department of Pathology,the Hospital of Hebei Engineering University Medical College,Handan 056002,China |
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| Abstract: | Objective:To detect the expression of CD44v6 and MMP-2 in infiltrating ductal carcinoma,and explore their relationship with lymph node metastasis.Methods:The expression of CD44v6 and MMP-2 was studied in 100 cases of infiltrating ductal carcinoma by SP immunohistochemistry.Results:The positive expression of CD44v6 protein in normal breast tissue and infiltrating ductal carcinoma was 12.5%(5/40),87%(87/100) respectively,and the positive rate of CD44v6 in patients with lymph node metastasis(56/60) significant... |
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| Keywords: | infiltrating ductal carcinoma CD44v6 MMP-2 metastasis |
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