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| 异氟烷对大鼠肝缺血再灌注肺组织损伤的保护作用研究 | |
| 引用本文： | 盖毅文,来炳祺,成少利,郭雄. 异氟烷对大鼠肝缺血再灌注肺组织损伤的保护作用研究[J]. 陕西医学杂志, 2011, 40(1): 15-17 |
| 作者姓名： | 盖毅文 来炳祺 成少利 郭雄 |
| 作者单位： | 1. 西安交通大学医学院第一附属医院麻醉科,西安,710061 2. 陕西省肿瘤医院麻醉科 3. 西安交通大医学院 |
| 基金项目： | 陕西省社发攻关基金资助(No2006K12-G5(3)) |
| 摘 要： | 目的:探讨异氟烷对大鼠肝缺血再灌注后肺损伤的保护作用。方法:将20只SD大鼠随机分为两组,每组10只。两组均用氯胺酮(1m g/kg)基础麻醉。对照组进行假手术,吸入组应用异氟烷持续吸入维持麻醉后进行手术,肝脏缺血再灌注后取肺脏灌洗液以及肺组织标本。测定NF-κB的含量以及肺组织形态学观察。结果:异氟烷对实验动物维持麻醉,可以有效地降低肺组织以及肺泡灌洗液中NF-κB的含量,肺组织损伤性变化减轻。结论:异氟烷对大鼠肝缺血再灌注肺组织损伤具有明显的保护作用。 |
| 关 键 词： | 再灌注损伤/药物作用 氧化合物/治疗应用 氯胺酮/治疗应用 模型,动物 大鼠 |
Protective effects of Isoflurane on lung injury from hepatic ischemia-reperfusion in rats |
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| Gai Yiwen Lai binqi Cheng Shaoli et al. Protective effects of Isoflurane on lung injury from hepatic ischemia-reperfusion in rats[J]. Shaanxi Medical Journal, 2011, 40(1): 15-17 | |
| Authors: | Gai Yiwen Lai binqi Cheng Shaoli et al |
| Affiliation: | Gai Yiwen Lai binqi Cheng Shaoli et al Department of Anesthesiology,the First Affiliated Hospital of Medical College,Xi'an Jiaotong University(Xi'an 710061) |
| Abstract: | Objective: To study the protective effects of Isoflurane on lung injury from hepatic ischemia-reperfusion in rats.Methods: 20 rats were randomly divided into two groups with 10 rats each group.The two groups were performed basic anesthesia with ketamine(1mg/kg).sham surgery for control group,while experimental group were inhalationally anesthetized with Isoflurane to maintain anesthesia during surgery in the same time.In two groups after hepatic ischemia-reperfusion,lung lavage fluid and lung tissue were sa... |
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