| 培菲康联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床疗效观察 |
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| 引用本文： | 师永盛,霍丽娟,安丽婷. 培菲康联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床疗效观察[J]. 山西医科大学学报, 2011, 42(3): 222-225. DOI: 10.3969/J.ISSN.1007-6611.2011.03.013 |
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| 作者姓名： | 师永盛 霍丽娟 安丽婷 |
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| 作者单位： | 山西医科大学第一临床医学院消化科,太原,030001 |
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| 摘 要： | 目的评价培菲康联合美沙拉嗪治疗轻、中度溃疡性结肠炎(UC)的临床疗效及作用机制。方法选取活动期轻、中度UC患者60例,随机分成2组。联合用药组(n=30),采用培菲康联合美沙拉嗪治疗;美沙拉嗪组(n=30),单用美沙拉嗪治疗,疗程为8周。于治疗前后评估临床症状及结肠镜下病变活动性,并取结肠黏膜活检,免疫组织化学染色检测两组患者用药前后NF-κB的表达。结果治疗后联合用药组临床症状和结肠镜下病变活动性较美沙拉嗪组明显改善(P<0.05),患者结肠黏膜NF-κB表达亦明显低于美沙拉嗪组(P<0.05)。结论培菲康联合美沙拉嗪治疗活动期轻、中度UC较单用美沙拉嗪效果好,其机制可能是通过抑制NF-κB而起到治疗作用的。
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| 关 键 词： | 益生菌 培菲康 溃疡性结肠炎 核因子-κB 免疫组织化学法 |
Clinical efficacy of combining bifico with mesalazine in treatment of mild to moderate ulcerative colitis |
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| SHI Yong-sheng,HUO Li-juan,AN Li-ting. Clinical efficacy of combining bifico with mesalazine in treatment of mild to moderate ulcerative colitis[J]. Journal of Shanxi Medical University, 2011, 42(3): 222-225. DOI: 10.3969/J.ISSN.1007-6611.2011.03.013 |
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| Authors: | SHI Yong-sheng HUO Li-juan AN Li-ting |
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| Affiliation: | SHI Yong-sheng,HUO Li-juan,AN Li-ting(Dept of Gastroenterology,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China,) |
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| Abstract: | Objective To evaluate the clinical efficacy of bifico combined with mesalazine in patients with mild to moderate ulcerative colitis(UC),and to explore its mechanism.Methods Sixty patients with mild to moderate active UC were randomized to combination group(n=30) and mesalazine group(n=30).The patients were treated by bifico and mesalazine in combination group and only by mesalazine in mesalazine group for 8 weeks.The changes of clinical symptoms and disease activity under endoscopy were evaluated before and... |
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| Keywords: | probiotics bifico ulcerative colitis nuclear factor-kappa B immunohistochemistry |
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