Cyclotron production of carrier-free 66Ga as a positron emitting label of albumin colloids for clinical use期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Cyclotron production of carrier-free 66Ga as a positron emitting label of albumin colloids for clinical use

Authors:	Patrick Goethals Manuella Coene Guido Slegers Philippe Agon Joris Deman Karel Schelstraete

Institution:	(1) Institute for Nuclear Sciences, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000 Gent, Belgium;(2) Laboratory of Analytical Chemistry (Faculty of Pharmaceutical Sciences), Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000 Gent, Belgium;(3) Heymans Institute of Pharmacology, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000 Gent, Belgium;(4) Department of Radiotherapy and Nuclear Medicine, Rijksuniversiteit Gent, Proeftuinstraat 86, B-9000 Gent, Belgium

Abstract:	A method for producing carrier free ⁶⁶Ga (T_1/2:9.4h; ⁺) by ⁴He bombardment of natural copper targets is presented. ⁶⁶Ga is formed by means of the ⁶³Cu (⁴He, n) ⁶⁶Ga reaction. Production yields are given in the 17.5 to 8 MeV ⁴He energy range. Chemical purification of ⁶⁶Ga from the copper target is described. The only radionuclidic impurity found in the final product was ⁶⁷Ga. Albumin colloids from commercially available kits designed for use with ^99mTc could easily be labeled with ⁶⁶Ga and employed for studies of the lymphatic system by positron emission tomography.

Keywords:	⁶⁶Ga production ⁶⁶Ga-albumin PET (positron-emission tomography) Lymphatic transport
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