Elevated gastric acid secretion in patients with Barrett's metaplastic epithelium |
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Authors: | Dr. Michael W. Mulholland MD PhD Brian J. Reid MD PhD Douglas S. Levine MD Cyrus E. Rubin MD |
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Affiliation: | (1) Departments of Surgery and Medicine, University of Washington, Seattle, Washington;(2) Department of Surgery, 2920 Taubman Health Care Center, 1500 E. Medical Center Drive, 49109 Ann Arbor, Michigan |
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Abstract: | Gastric acid secretion in response to a protein meal and to exogenously administered synthetic human gastrin 17-I was measured in patients with Barrett's esophagus, patients with uncomplicated gastroesophageal reflux, and normal age- and sex-matched controls. Acid secretion, both basally and in response to gastrin 17-I, was significantly greater in patients with Barrett's esophagus compared to normal individuals without reflux. Basal gastrin levels and meal-stimulated levels of the hormone were similar among all three groups. Sensitivity to gastrin, expressed as the concentration causing half-maximal acid secretion, was also similar among the study groups. It is speculated that elevated basal acid production in Barrett's esophagus may contribute to the pathogenesis of the disorder.Study supported by Smith, Kline, and French, Inc. |
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Keywords: | Barrett esophagus reflux gastrin acid cimetidine |
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