Additive immunosuppressive effect of hydroxycamptothecin and cyclosporine on rejection of heart transplantation in rats |
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| Authors: | Shi B Cai M Qian Y Zhou W Mo C Wang Y |
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| Institution: | Transplantation Center, Second Affiliated Hospital, General Hospital of PLA, Beijing, People's Republic of China. |
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| Abstract: | OBJECTIVE: The objective of this study was to study the inhibitory effects of hydroxycamptothecin (HCPT) and cyclosporine (CsA) on heart transplantation rejection in rats. MATERIALS AND METHODS: Inbred SD rats were used as donors and inbred Wistar rats as recipients. Cervical heterotopic heart transplantation was performed in 40 rats: group A received placebo; group B, HCPT; group C, CsA; group D, HCPT+CsA. RESULTS: The mean survival time was prolonged in group D with 5 grafts beating at more than 730 days. CONCLUSION: HCPT combined with CsA prevented acute rejection of allogeneic heart transplantations in rats, significantly prolonging graft mean survival time. |
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