In vivo metabolic activity of the suprachiasmatic nuclei: a comparative study |
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| Authors: | William J. Schwartz Steven M. Reppert Sharon M. Eagan Martin C. Moore-Ede |
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| Affiliation: | 1. Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, U.S.A.;2. Children''s Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114U.S.A.;3. Department of Physiology and Biophysics, Harvard Medical School, Boston, MA 02115, U.S.A. |
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| Abstract: | In vivo glucose utilization was measured in the suprachiasmatic nuclei (SCN) of the rat, monkey, and cat using the 14C-labeled deoxyglucose technique. SCN metabolic activity in all species was endogenously rhythmic with high levels during the subjective daylight portion of the 24 h day. Such phase conservation across night-, day-, and randomly-active species is in agreement with formal analyses of the properties of entrainable circadian oscillators, and our data suggest that the biochemical processes which underlie the activity of this circadian clock are similar in mammals with differing patterns of expressed circadian rhythmicity. |
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| Keywords: | circadian rhythmicity suprachiasmatic nuclei 14C-labeled deoxyglucose |
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