四川省11021名居民食管癌普查结果分析

目的:了解食管癌高发区人群食管癌及癌前病变的患病情况,达到早诊早治的目的.方法:在食管癌高发地区,采取整群随机抽样的方法选择至少1个乡或村作为筛查对象,对40～69岁人群采取内镜下碘染色及指示性活检技术进行筛查,并经病理确诊.结果:全省合计筛查11 021人,筛查率为100.19％；食管重度异形增生(重增)/原位癌及以上患者检出率为1.52％(168/11 021),早诊率为67.86％(114/168),治疗率为67.26％(113/168).食管轻度增生检出率为4.76％(525/11 021),中度增生检出率为1.65％(182/11 021),重增/原位癌检出率为0.97％(107/11 021),黏膜内癌检出率为0.05％(6/11 021),黏膜下癌检出率为0.01％(1/11 021),中晚期浸润癌检出率为0.49％(54/11 021),食管癌检出率为0.55％(61/11 021).各项目点轻、中和重度增生的检出率之间差异有统计学意义,P＜0.05；食管癌的检出率差异无统计学意义,P=0.846.结论:食管癌高发区居民中存在一定数量的癌前病变患者,对该部分人群进行食管癌普查,并进行癌症综合知识宣传,是做好食管癌二级预防的关键.

Analysis of the census results of esophageal cancer among 11 021 residents in Sichuan province

OBJECTIVE:To study the prevalence of esophageal and precancerous lesions in high risk areas in order to early diagnosis and treatment.METHODS:Take random cluster sampling method to select at least one township or village as a screening object in high risk areas.Endoscope iodine staining and index biopsy screening method were used for 40-69 years old people and the pathology confirmed the diagnosis.RESULTS:This study was screened 11 021 people and the screening rate was 100.19%.Severe esophageal displasia and carcinoma in situ and other lesions detection rate were 1.52%(168/11 021).Early diagnosis rate was 67.86%(114/168).Treatment rate was 67.26%(113/168).Mild esophageal displasia detection rate was 4.76%(525/11 021).Moderate displasia detection rate was 1.65%(182/11 021).Severe esophageal displasia detection rate was 0.97%(107/11 021).Mucous membrane in carcinoma detection rate was 0.05%(6/11 021).Submucosal carcinoma detection rate was 0.01%(1/11 021).Middle-late esophageal cancer detection rate was 0.49%(54/11 021).Esophageal cancer detection rate was 0.55%(61/11 021).The difference of mild,moderate,severe esophageal displasia detection rate between each census unit was statistically significant(P<0.05).Esophageal cancer detection rate between each census unit was not statistically significant(P=0.846).CONCLUSIONS:There was a certain number of precancerous lesions in the esophageal in high incidence area residents in the part of the population for esophageal census and the comprehensive cancer provention education.It is the key for the secondary prevention of esophageal cancer.