Successful Elimination of SARS-CoV-2 Following Vaccination with BNT162b2 after Prolonged Viral Infection in an Immunocompromised Lymphoma Patient |
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| Authors: | Masao Hagihara Yui Imai Tomoyuki Uchida Shin Ohara Morihiro Inoue Tomiyuki Sugi Keiko Mitamura |
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| Institution: | 1.Department of Hematology, Eiju General Hospital, Japan; 2.Department of Pharmacy, Eiju General Hospital, Japan; 3.Department of Preventive Medicine, Eiju General Hospital, Japan |
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| Abstract: | A 52-year-old man with mantle cell lymphoma treated with bendamustine and rituximab developed prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Despite elevated titers of anti-spike IgG antibody, protracted pancytopenia persisted for more than six months. Finally, the anti-SARS CoV-2 vaccine, BNT162b2, was administered, which improved his blood cell count and eliminated the virus. The increased anti-spike IgG titer and lymphocyte count after vaccination suggested that both humoral and cellular immunity acted in coordination to eliminate the virus. |
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| Keywords: | SARS-CoV-2 bendamustine prolonged infection vaccine anti-spike IgG cellular immunity |
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