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| 血管内皮细胞生长因子和血管生成与大肠癌发展关系的研究 | |
| 引用本文： | 徐少勇,刘重贞,彭铁立,易建华,于皆平. 血管内皮细胞生长因子和血管生成与大肠癌发展关系的研究[J]. 中国慢性病预防与控制, 2000, 8(4): 171-173 |
| 作者姓名： | 徐少勇 刘重贞 彭铁立 易建华 于皆平 |
| 作者单位： | 1. 郧阳医学院,附属太和医院消化内科,湖北,十堰,442000 2. 郧阳医学院,附属太和医院病理科,湖北,十堰,442000 3. 湖北医科大学,附属第一医院消化内科,湖北,武汉,430000 |
| 摘 要： | 目的：探讨血管内皮细胞生长因子和血管生成与大肠癌发展的关系。方法：应用免疫组化Ｓ－Ｐ法，检测６２例人大肠癌组织ＶＥＧＦ蛋白表达和微血管密度（ＭＶＤ），分析ＶＥＧＦ和ＭＶＤ、及其与大肠癌组织学分型、Ｄｕｋｅｓ分期、癌肿浸润转移的关系。结果：ＶＥＧＦ表达强度和ＭＶＤ与大肠癌的Ｄｕｋｅｓ分期（Ｐ〈０．０５）、淋巴结转移（Ｐ〈０．０５）及远处转移（Ｐ〈０．０１）密切相关，而与组织学分型无关（Ｐ〈０．０５） |
| 关 键 词： | 大肠部 血管内皮生长因子 血管生成 转移 |
| 修稿时间： | 2000-04-22 |
The Relationship Between Vascular Endothelial Growth Factor,Angiogenesis and the Development of Colorectal Carcinoma |
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| XU Shao yong,et al. The Relationship Between Vascular Endothelial Growth Factor,Angiogenesis and the Development of Colorectal Carcinoma[J]. Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases, 2000, 8(4): 171-173 | |
| Authors: | XU Shao yong et al |
| Affiliation: | XU Shao yong,et al,Department of Digestion,Taihe Hospital of Yunyang Medical College,Hubei Shiyan 442000,China |
| Abstract: | Objective:To investigate the relationship between vascular endothelial growth factor (VEGF),angiogenesis and the development of colorectal carcinoma.Methods:VEGF protein expression and microvessel density(MVD) in 62 colorectal cancers were examined by means of immunohistochemical staining.MVD and VEGF expression and their relationships were analyzed together with histologic types,Dukes period and metastasis of colorectal carcinoma.Results:MVD and VEGF expression positively correlated with Dukes period ( P <0 05),lymph node metastasis( P <0 05) and distant metastasis( P <0 01),but no significant correlation with the histologic type( P >0 05).There was a positive correlation between MVD and VEGF expression ( r =0 89).Conclusions:VEGF is highly related to angiogenesis of colorectal carcinoma and promotes growth,invasion and metastasis of co lorectal carcinoma.VEGF expression or MVD may be one of the predictors for the biological behavior of colorectal carcinoma. |
| Keywords: | Colorectal carcinoma Vascular endothelial growth factor Angiogenesis Metastasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |