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Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils |
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| Authors: | Hiroto Ichiki Toshihiko Kuroiwa Ikuo Taniguchi Riki Okeda |
| Institution: | aDepartment of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113 Japan;bDepartment of Neurophysiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan;cDepartment of Otolaryngology, Japan Self-Defense Forces Central Hospital, Tokyo, Japan |
| Abstract: | Early detection of irreversible neuronal change after transient cerebral ischemia is important so that adequate treatment can be initiated within the therapeutic window. We have examined the correlation between changes in middle-latency auditory evoked potentials (MAEPs) and histological changes in the auditory cortex of awake Mongolian gerbils subjected to 4 min or 12 min of transient cerebral ischemia. Post-ischemic MAEPs were characterized by the appearance of a markedly large negative and positive component at approximately 17–22 ms latency in both groups. Delay in the appearance of the high amplitude (maximal amplitude at 45 min after recirculation in the 12-min ischemia group) precedes the slowly developing death of neurons in the auditory cortex that results from transient cerebral ischemia. |
| Keywords: | Middle-latency auditory evoked potential Gerbil Auditory cortex Transient cerebral ischemia Neuronal death |
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