Family history for venous thromboembolism and the risk for recurrence |
| |
Authors: | Hron Gregor Eichinger Sabine Weltermann Ansgar Minar Erich Bialonczyk Christine Hirschl Mirko Stain Milena Gartner Verena Kyrle Paul Alexander |
| |
Institution: | a Department of Internal Medicine I, Division of Angiology, Medical University of Vienna, Vienna, Austria. b Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria. c Department of Dermatology, Wilhelminenspital, Vienna, Austria. d Department of Internal Medicine, Hanusch Krankenhaus, Vienna, Austria. |
| |
Abstract: | PurposeThe relevance of a family history for venous thromboembolism with regard to the likelihood for recurrence is unknown.Subjects and methodsWe studied 826 patients for an average of 36 months after a first unprovoked venous thromboembolism and withdrawal of oral anticoagulation. Patients with cancer, lupus anticoagulant, or deficiency of antithrombin, protein C, or protein S were excluded. The study endpoint was objective evidence of recurrent symptomatic venous thromboembolism.ResultsRecurrence for venous thromboembolism was recorded in 23 of 190 patients (12.1%) with a family history (at least one affected first-degree family member) and in 79 of 636 patients (12.4%) without familial thrombosis (relative risk for recurrence 1.0; 95% confidence interval, 0.7-1.6; P = .9). At 5 years, the likelihood for recurrence was 20% among patients with a family history for venous thromboembolism and 18% among those without a family history for venous thromboembolism (P = .9). Risk determinants for venous thromboembolism including factor V Leiden, factor II G20210A, and high factor VIII were not statistically different between the 2 groups.ConclusionA family history for venous thromboembolism does not segregate patients into high- or low-risk categories and is not suitable to identify patients at increased risk for recurrent venous thromboembolism. |
| |
Keywords: | Deep vein thrombosis Recurrence Family history |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|