| 注射用硫酸依替米星Ⅲ期临床试验 |
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| 引用本文： | 周际安 田德英 杨道峰 郑经川 何礼贤 陈尔章 李丽云 周霞英吕晓菊 陈亚岗 余春艳 陈雪华 胡必杰 曹赵龙 赵宗珉 黄晶 俞汝佳. 注射用硫酸依替米星Ⅲ期临床试验[J]. 中国抗生素杂志, 2000, 25(Z1): 1-5 |
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| 作者姓名： | 周际安 田德英 杨道峰 郑经川 何礼贤 陈尔章 李丽云 周霞英吕晓菊 陈亚岗 余春艳 陈雪华 胡必杰 曹赵龙 赵宗珉 黄晶 俞汝佳 |
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| 摘 要： |
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Themulti-center clinical study of etimicin injection againstacute bacterial infections |
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| Abstract: | Toevaluate the efficacy and safety of etimicin injection, 2212 patients with acute bacterialinfections in respiratory tract, urinary tract, digestive tract, and other infections weretreated with the drug in an opened trial. Etimicin were administered single (100mg, q12hor 200mg, qd) or association (combinated with other antimicrobial agents sanctioned bygovernment) for 5～10days. The results showed that the total cure rate, effective rate, bacterial clearancerate and adverse reaction rate were 61.2%, 91.8%, 91.7%, 4.33% respectively for singleadministered and 48.5%, 85.1%, 88.6%, 4.4% respectively for association administered. Themostly adverse reactions were generally mild and well tolerated. Only 14 patients occurhypoacusis (0.73%); 7 patients occur hepatic or renal function disorders (0.37%). Theresults indicated that etimicin injection is an effective and safe drug with lower toxity,and may contribute to treat the patients with serious bacterial infections combinated withother antibiotics. |
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