Reversible morphological changes in human breast fibroblasts exposed to stilboestrol |
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| Authors: | P A Riley A Latter P M Sutton |
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| Affiliation: | Division of Pathology, University College Hospital Medical School, University Street, London, W.C.1., United Kingdom |
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| Abstract: | Fibroblast cultures derived from human breast material treated with pharmacological doses of stilboestrol (115 μm) undergo a morphological transformation to an epithelial appearance. The effect is rapid and reversible. It is independent of RNA and protein synthesis and is not inhibited by an oestrogen antagonist (tamoxifen). |
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