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| 20(R)-原人参二醇酸水解条件的工艺研究 | |
| 引用本文： | 杨雅淇,郑新涛,赵余庆.20(R)-原人参二醇酸水解条件的工艺研究[J].中国现代中药,2011,13(8):36-39. |
| 作者姓名： | 杨雅淇 郑新涛 赵余庆 |
| 作者单位： | 1. 辽宁中医药大学,辽宁,沈阳,110032 2. 沈阳药科大学,辽宁,沈阳,110016 3. 沈阳药科大学,辽宁,沈阳,110016;基于靶点的药物设计与研究重点实验室,辽宁,沈阳,110016 |
| 基金项目： | 辽宁省天然产物现代分离与工业化制备工程技术中心 |
| 摘 要： | 目的:优化三七茎叶总皂苷的盐酸水解工艺,提高水解产物20(R)-原人参二醇20(R)-protopanaxadiol,20(R)-PPD]的产率。方法:采用正交试验设计,考察料液比、盐酸浓度、水解时间、水解温度对三七茎叶总皂苷水解过程的影响。结果:影响水解的主次因素依次是盐酸浓度>料液比>水解温度>水解时间,优选的最佳工艺为料液比1∶1;盐酸浓度17.1mol·L-1,水解时间90min,水解温度50℃。结论:采用优化后的水解条件能够提高PPD的转化率,适合工业化生产。 |
| 关 键 词： | 三七茎叶总皂苷 盐酸水解 PPD |
| 收稿时间： | 4/6/2011 12:00:00 AM |
Study on the Technology of Hydrolysis Process of 20(R)-PPD with Hydrochloric Acid |
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| YANG Ya-qi,ZHENG Xin-tao and ZHAO Yu-qing.Study on the Technology of Hydrolysis Process of 20(R)-PPD with Hydrochloric Acid[J].Modern Chinese Medicine,2011,13(8):36-39. | |
| Authors: | YANG Ya-qi ZHENG Xin-tao and ZHAO Yu-qing |
| Institution: | YANG Ya-qi1,ZHENG Xin-tao2,ZHAO Yu-qing2,3 (1.Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China,2.Shenyang Pharmaceutical University,Shenyang 110016,3.Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University,China) |
| Abstract: | Objective:To optimize the hydrolysis technology of total saponins in Panax notoginseng with hydrochloric acid in order to increase the yield of 20(R)-PPD. Methods: Orthogonal design was used to optimize the hydrolysis condition and four factors including solid/liquid ratio,concentration,reaction time and reaction temperature were investigated to study the process of hydrolysis. Results: The primary and secondary influence factors of this process were listed as follows: concentration>solid/liquid ratio>tempe... |
| Keywords: | Total panax notoginseng saponins Hydrolysis PPD |
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