| 组织多肽特异性抗原对胰腺癌患者的诊断价值 |
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| 引用本文： | 陆云,刘兴党,李鼎,邓守真. 组织多肽特异性抗原对胰腺癌患者的诊断价值[J]. 中华核医学杂志, 2002, 29(1): 194-196. DOI: 10.3760/cma.j.issn.0253-9780.2009.03.015 |
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| 作者姓名： | 陆云 刘兴党 李鼎 邓守真 |
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| 作者单位： | 复旦大学附属华山医院核医学科,上海,200040; |
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| 摘 要： | Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma.
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| 关 键 词： | 抗原,肿瘤 抗原,肿瘤相关,碳水化合物 胰腺肿瘤 |
Diagnostic value of tissue polypeptide specific antigen in serum for patients with pancreatic carcinoma |
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| Abstract: | |
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| Keywords: | Antigens neoplasmsAntigens tumor-associated carbohydratePancreatic neoplasms |
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