| 药物致心律失常及其评价模型研究进展 |
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| 引用本文： | 岳慧杰,王友群.药物致心律失常及其评价模型研究进展[J].中国现代应用药学,2007,24(4):285-288. |
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| 作者姓名： | 岳慧杰 王友群 |
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| 作者单位： | 中国药科大学药理研究室,南京,210009 |
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| 摘 要： | 目的综述药物致心律失常的可能机制,对模型做一简要回顾评价,为找出合适的临床前评价模型提供帮助。方法检索近几年的文献资料进行分析归纳。结果与讨论只有对药物致心律失常的机制充分掌握,才能建立合适的模型预防心律失常。
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| 关 键 词： | 药物致心律失常 长QT综合征 尖端扭转性室性心动过速 跨室壁复极化离散度 模型 |
| 文章编号： | 1007-7693（2007）04-0285-04 |
| 修稿时间： | 2006-10-18 |
Development of Drug-induced Arrhythmias and its Models for Assessment |
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| YUE Hui-jie,WANG You-qun.Development of Drug-induced Arrhythmias and its Models for Assessment[J].The Chinese Journal of Modern Applied Pharmacy,2007,24(4):285-288. |
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| Authors: | YUE Hui-jie WANG You-qun |
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| Institution: | The Department of Pharmacology of China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | OBJECTIVE To find suitable models for preclinical safety evaluation of drug-induced arrhythmias by summarizing the possible mechanisms and assessment models of drug-induced arrhythmias.METHODS Summarizing and analyzing the literatures and data published in the recent years. RESULTS AND CONCLUSION The design of suitable models to efficiently prevent arrhythmias was based on the sufficient understand of the exact mechanism for drug-induced arrhythmias. |
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| Keywords: | drug-induced arrhythmias long QT syndrome torsade de pointes transmural dispersion of repolarization models |
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