| 低剂量阿司匹林配伍来曲唑对PCOS不孕患者临床妊娠率的影响 |
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| 引用本文： | 张秀玲. 低剂量阿司匹林配伍来曲唑对PCOS不孕患者临床妊娠率的影响[J]. 医学理论与实践, 2011, 24(12): 1398-1400 |
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| 作者姓名： | 张秀玲 |
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| 作者单位： | 山东省成武县人民医院妇产科,274200 |
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| 摘 要： | 目的:将来曲唑+阿司匹林与克罗米酚分别应用于多囊卵巢综合征(PCOS)97例诱导排卵治疗,比较来曲唑+阿司匹林及克罗米酚对卵泡发育及子宫内膜及妊娠率的影响。方法:选择PCOS不孕患者97例,随机分为两组,来曲唑+阿司匹林组47例,克罗米酚组50例。来曲唑+阿司匹林组均于月经来潮或撤退性出血第3~5天口服来曲唑2.5mg(1次/d)共5d+阿司匹林50mg(2次/d)(至妊娠10周);克罗米酚组均于月经来潮或撤退性出血第3~5天口服克罗米酚100mg(1次/d)共5d,观察两组PCOS患者卵泡发育、子宫内膜及妊娠情况。结果:来曲唑+阿司匹林组出现优势卵泡40例(85.11%),克罗米酚组31例(62.00%)(P<0.05);来曲唑+阿司匹林组单卵泡发育33例,克罗米酚组单卵泡发育13例(P<0.05);来曲唑+阿司匹林组HCG注射日子宫内膜厚度来为(10.13±1.45)mm,克罗米酚组(5.79±0.91)mm(P<0.01);来曲唑+阿司匹林组妊娠率明显高于克罗米酚组(P<0.05)。结论:来曲唑配伍阿司匹林促排卵治疗PCOS无排卵不孕,促排卵效果好,单卵泡发生率高,子宫内膜厚度明显高于克罗米酚组,有助于改善妊娠周期中子宫内膜的容受性,具有良好的排卵率和妊娠率,降低流产率。
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| 关 键 词： | 不孕症 多囊卵巢综合征 来曲唑+阿司匹林 克罗米酚 促排卵 卵泡发育 子宫内膜 妊娠率 |
Influence of Low Dose Aspirin and Letrozole on Clinical Pregnancy Rate of PCOS Infertile Patients |
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| ZHANG Xiuling. Influence of Low Dose Aspirin and Letrozole on Clinical Pregnancy Rate of PCOS Infertile Patients[J]. The Journal of Medical Theory and Practice, 2011, 24(12): 1398-1400 |
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| Authors: | ZHANG Xiuling |
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| Affiliation: | ZHANG Xiuling.Department of Obstetrics and Gynecology,The People's Hospital of Chengwu County,Shandong Province 274200 |
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| Abstract: | Objective:Letrozole and clomiphene citrate aspirin were used for polycystic ovary syndrome(PCOS)97 patients ovulation induction treatment,Aspirin letrozole and clomiphene citrate on follicular development and endometrial and pregnancy rate was compared.Methods:97 cases of PCOS infertile patients selected were randomly divided into two groups:letrozole+aspirin group of 47 patients,Clomiphene citrate group of 50 patients.Letrozole+aspirin group was withdrawal bleeding or menstrual cramps 3~5 days of oral letr... |
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| Keywords: | Infertility Polycystic ovarian syndrome(PCOS) Letrozole and aspirin Clomiphene citrate Ovulation induction Follicular development Endometrium Pregnancy rates |
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