Reduction of neophobia in mice following lesions of the caudate-putamen |
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| Authors: | M Cigrang E Vogel R Misslin |
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| Affiliation: | 1. Institute for Neuroscience, Texas A&M University, College Station, TX 77843-3474, United States;2. Department of Psychology, Texas A&M University, College Station, TX 77843-3474, United States;1. Department of Gerontology and Geriatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, the Netherlands;2. Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Center tower, Baltimore, MD 21224, United States;3. Department of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, the Netherlands;1. Mrs. T.H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, 1540 Alcazar St, Los Angeles, CA 90089, United States;2. Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, 15 Michigan St NE, Grand Rapids, MI 49503, United States;3. Bioinformatics and Biostatistics Core, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, United States;4. Department of Pediatrics, Children’s Hospital of Los Angeles, Keck School of Medicine, University of Southern California, 4651 Sunset Blvd, Los Angeles, CA 90027, United States;1. University of Cincinnati, College of Medicine, Cincinnati, OH, United States;2. University of Minnesota, College of Liberal Arts, Minneapolis, MN, United States;1. Laboratory of Veterinary Anatomy and Cell Biology, Faculty of Agriculture, Iwate University, 18-8, Ueda 3-Chome, Morioka, Iwate 020-8550, Japan;2. Department of Basic Veterinary Science, United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Japan |
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| Abstract: | Electrolytic lesions of the caudate-putamen result in a significant decrease in neophobic responses in mice towards a novel object introduced into their familiar environment; however, preference for a novel environment was not altered by the lesion. These data provide a parallel between the effects of lesions of the caudate-putamen and the well-known "amygdala-lesion-syndrome." It is suggested that the striatal complex, which receives massive afferent projection systems, plays a crucial role in sensory-motor integration processes which allow the animals to adapt their responses towards biological significant stimuli in order to cope with their environment. |
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