大肠癌中CD44V6、CD44s表达与nm23-H1表达相关性及临床意义

目的　了解CD4 4V6 、CD4 4s、nm2 3-H1 在结直肠癌组织、移行粘膜及正常粘膜间的表达 ,探讨它们与结直肠癌侵袭与转移的关系。方法　运用免疫组化SABC法测定CD4 4V6 、CD4 4s、nm2 3-H1 在癌组织、癌远端 3cm处的移行组织及正常结直肠组织中的表达 ,同时记录有关的临床病理指标。结果　CD4 4V6 、、CD4 4s、nm2 3-H1 阳性表达率分别在癌组织中为 70 .18%、4 2 .11%及 5 4 .39%与移行组织中 12 .0 2 %、89.4 7%、91.2 %及正常结直肠组织中 0、10 0 %、94 .74 % ,其差别有显著性 (P <0 .0 5 )。CD4 4V6 表达与肿瘤侵袭深度、Dukes分期及淋巴结转移正相关 ,nm2 3-H1 表达与Dukes分期、淋巴结转移呈负相关 (P <0 .0 5 )。CD4 4s在移行粘膜与正常组织表达有显著差别 (P <0 .0 5 )。结论　结直肠癌组织CD4 4V6 表达增多 ,CD4 4s及nm2 3-H1 表达降低。CD4 4V6 及nm2 3-H1 与结直肠癌的侵袭与转移有关 ,CD4 4V6 变化较nm2 3-H1 在前。直肠癌手术时癌远端至少应切除 3cm长的肠管

Relation between gene expression of CD44V6、 CD44s、 nm23-H1 and invasion, metastasis in colorectal carcinoma

Objective The aims of this paper was to investigate the expression of CD44V 6 (cluster of differentiation V 6), CD44s, nm23-H 1 (nonmetastatic gene 23 H 1) in tumor tissue, migratory mucosa and normal colorectal mucosa, to clarify the relationship between CD44V 6, CD44s, nm23-H 1 as parameters of tumor and invasion, metastasis in colorectal carcinoma. Methods CD44V 6, CD44s, nm23-H 1 were detected using immuno-histochemistry in 57 colorectal carcinomas, the clinicopathological characteristics were recorded. Results 70.18%, 42.11%, 54.39% of CD44V 6, CD44s, nm23-H 1 respectively expressed positively in tumor tissue to differ significantly in migratory mucosa 12.02%, 89.47%, 91.2% respectively and in normal colorectal mucosa 0, 100%, 94.74% respectively (P<0.05). The expression of CD44V 6 was statistically significantly positive correlation with lymph-node metastasis, Dukes' stage and invasive depth (P<0.05). The expression of nm23-H 1 was statistically lower in tumor inversely associated with lymph-node metastasis, Dukes' stage (P<0.05). Conclusions Colorectal tumor tissue has overexpression of CD44V 6 But lowerexpression of nm23-H 1. Both CD44V 6 and nm23-H 1 were assiociated with invasion and metastasis. Because of change of the expression of CD44s in migratory mucosa, the rectum 3 centimeters far to tumor should be resected in rectal carcinoma.