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Molecular and biochemical pharmacology of the histamine H4 receptor |
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| Authors: | Rob Leurs Paul L Chazot Fiona C Shenton Herman D Lim Iwan JP de Esch |
| Affiliation: | 1.Department of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands;2.School of Biological and Biomedical Sciences, Durham University, Durham, UK |
| Abstract: | The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor. |
| Keywords: | histamine H4 receptor molecular pharmacology biochemistry signal transduction species difference isoforms heterogeneity selective agonists and antagonists |