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Vernonia Amygdalina Del. stimulated glucose uptake in brain tissues enhances antioxidative activities; and modulates functional chemistry and dysregulated metabolic pathways |
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| Authors: | Erukainure Ochuko L. Oyebode Olajumoke A. Ibeji Collins U. Koorbanally Neil A. Islam Md. Shahidul |
| Affiliation: | 1.Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa ;2.Nutrition and Toxicology Division, Federal Institute of Industrial Research, Oshodi, Lagos, Nigeria ;3.Department of Pure and Industrial Chemistry, Faculty of Physical Sciences, University of Nigeria, Nsukka, 410001, Nigeria ;4.School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa ; |
| Abstract: | Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Hot infusion of V. amygdalina leaves was incubated with rat brain tissues for 2 h in the presence of glucose. Another incubation with glucose only, served as negative control while metformin served as positive control. Incubation of brain tissues with V. amygdalina led to significant (p?V. amygdalina. |
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