Autoantibodies in systemic sclerosis |
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| Authors: | Sonal Mehra Jennifer Walker Karen Patterson Marvin J Fritzler |
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| Institution: | 1. Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta, Canada, T2N 4N1;2. Department of Immunology, Allergy and Arthritis, Flinders Medical Centre, Adelaide, Australia;3. Flinders University of South Australia, Australia;1. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD candidate in Medical Sciences, Universidade Federal do Rio Grande do Sul – UFGRS;2. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD in Medicine, UFGRS; Immunologist Physician, Hospital de Clínicas de Porto Alegre – HCPA, UFGRS;3. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD in Medicine, UFGRS; Physician, Rheumatology Service, Hospital Nossa Senhora da Conceição, Grupo Hospitalar Conceição – HNSC-GHC;4. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD in Life Sciences, Specialist in Immunology, Université de Paris V; Associate Professor, Department of Genetics, UFGRS;5. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD in Medicine, UFGRS; Associate Professor, Department of Internal Medicine, UFGRS;6. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD in Medicine, Immunologist Physician, Chief, Service of Immunology, HCPA-UFRGS; Associate Professor, Department of Internal Medicine, UFGRS;7. Serviço de Reumatologia and Serviço de Imunologia, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul -HCPA-UFRGS. PhD in Immunology, Shimane Medical University; Associate Professor, UFGRS; Chief, Service of Rheumatology, HCPA-UFRGS;1. Respiratory Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A90, Cleveland, OH 44195, USA;2. Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH, USA;1. Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA;2. Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA;1. Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil;2. Universidade de São Paulo, São Paulo, SP, Brazil |
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| Abstract: | Autoantibodies directed against a variety of nuclear, cytoplasmic and extracellular autoantigens are a serological hallmark of systemic sclerosis. This review provides an overview of the history and clinical association of many of the autoantibodies identified in SSc sera to date. Some of these autoantibodies predate the clinical diagnosis of SSc, some are pathogenic while others have no apparent role in pathogenesis. It was once thought that the autoantibody spectrum of individual SSc sera were less complex than other systemic autoimmune rheumatic diseases with respect to heterogeneous B cell responses reflected in circulating autoantibodies. However, with the advent of array technologies, there is now an unprecedented capability to detect multiple autoantibodies in an individual serum and this long held tenet of clinical diagnostic immunology is being reexamined. |
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